Potency · Safety · Cross-species coverage
From target to siRNA lead.
Without compromise.
TargetDesignCandidatesLead
Wuya Discovery helps RNAi teams design, screen, and optimize siRNA candidates through OligoThink™, an AI-driven platform connected directly to high-throughput wet-lab validation. Every experimental result sharpens the next round.
Experimentally validated in the wet lab.
OligoThink™ · siRNA Design AgentAI-guided design connected to wet-lab validationPUBLIC TARGET · SIMULATED DEMO DATATaskLPA
Design a lead-ready siRNA candidate panel for LPA. Prioritize predicted relative potency, human off-target safety, and cross-species coverage in rhesus and cynomolgus monkey. Exclude immunostimulatory motifs and nominate candidates for wet-lab validation.
I’ll map the target, generate candidate windows, rank relative performance, screen human off-target risk, and check primate coverage before nominating a wet-lab panel.
WorkspacePreparing design run
LPA design run is ready
Candidate ranking is relative within this simulated target run. No sequence or clinical result is shown.
DESIGN · SCREEN · NOMINATECandidatesCross-speciesOff-target
GenerationComplete
Risk screeningComplete
Wet-lab panel6 nominated
Top Candidates
Relative ranking · simulated| Candidate ID | Relative potency | GC content | Human off-target risk | Primate coverage | Immunostimulatory motif | Decision |
|---|---|---|---|---|---|---|
| LPA-021-01 | 0.94 | 43% | Low | Rhesus + Cyno | None flagged | Wet lab |
| LPA-021-02 | 0.91 | 48% | Low | Rhesus + Cyno | None flagged | Wet lab |
| LPA-020-03 | 0.87 | 45% | Low | Rhesus + Cyno | None flagged | Wet lab |
| LPA-019-04 | 0.82 | 42% | Review | Rhesus | None flagged | Review |
SIMULATED DEMO DATA · Relative potency is a within-run ranking score, not knockdown percentage and not a clinical result. Candidate sequences are intentionally withheld.